Is the role of the small intestine in first-pass metabolism overemphasized?
نویسندگان
چکیده
منابع مشابه
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Orally administered astemizole is well absorbed but undergoes an extensive first-pass metabolism to O-desmethylastemizole. Desmethylastemizole is formed in the human microsomal systems of the small intestine as well as the liver, which suggests the role of cytochromes P450 (P450s) in the first-pass metabolism of astemizole. Human P450s involved in the O-demethylation of astemizole have, however...
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عنوان ژورنال:
- Pharmacological reviews
دوره 51 2 شماره
صفحات -
تاریخ انتشار 1999